Study reveals vitamin B12 as inhibitor of key enzyme in hereditary Parkinsons

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Apr 3 2019Iban Ubarretxena, an Ikerbasque Researcher and Director of the Biofisika Institute (CSIC-UPV/EHU), participates in a piece of research that has enabled new inhibitors to be identified and which could be used to develop drugs to combat Parkinson’s. The research has been published in the prestigious journal Cell Research.Parkinson’s is the most common, chronic neurodegenerative movement disorder affecting 1% of the global population over seventy years of age. Right now, there is no cure for this disease and the available treatments focus on addressing its symptoms but not its progression.Although most cases of Parkinson’s are sporadic, the inheritable variants of the disease are mainly associated with mutations of the gene that encodes the LRRK2 enzyme. In 2004 an international research team, in which researchers from the Basque Country participated, established the link between one of the mutations in this enzyme and patients diagnosed with the disease.Related StoriesNovel device could enable early diagnosis and treatment development for Parkinson’s diseasePatients with bipolar disorder are seven times more likely to develop Parkinson’sFactors affecting absorption of ‘sunshine vitamin’ during spring/summer monthsSo the LRRK2 enzyme, which is also known internationally by the name “dardarina”, the Basque word that means tremor, has become one of the most attractive therapeutic targets for developing new drugs to combat inheritable Parkinson’s. Neurotoxicity, or the pathogenic effects as a whole associated with LRRK2, is mainly due to the fact that pathogenic mutations increase the kinase activity of this enzyme, which has prompted an international race to develop inhibitors. Right now, specific, powerful inhibitors of the kinase activity of LRRK2 do in fact exist. Yet many of them cause undesirable side effects or produce very unclear clinical results.This research conducted by Iban Ubarretxena, the Ikerbasque researcher and director of the Biofisika Institute (mixed centre of the CSIC-Spanish National Research Council and the UPV/EHU-University of the Basque Country) at the UPV/EHU’s Science Park (Leioa-Erandio Area), together with an international research team, has revealed that AdoCbl, one of the active forms of vitamin B12, acts as an inhibitor of the kinase activity of LRRK2 in cultured cells and brain tissue. It also significantly prevents the neurotoxicity of the LRRK2 variants associated with Parkinson’s in cultured cells of primary rodents, as well as in various genetically modified models used to study this disease. The results of the research have been published in the prestigious journal Cell Research.So according to the study, vitamin B12 has turned out to be a new class of modulator of the kinase activity of LRRK2, which, as Iban Ubarretxena pointed out, “constitutes a huge step forward because it is a neuroprotective vitamin in animal models and has a mechanism unlike that of currently existing inhibitors. So it could be used as a basis to develop new therapies to combat hereditary Parkinson’s associated with pathogenic variants of the LRRK2 enzyme”.Source: read more

Third time lucky for another Samsung leader

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Lee, 49, is vice chairman of Samsung Electronics, the world’s largest smartphone maker and the flagship of the Samsung Group founded by his grandfather in 1938. Lee’s father Lee Kun-Hee went on to build up the tech empire but was convicted of bribery in 1996. The Seoul Central District Court also found him guilty of tax evasion and other charges 10 years ago but suspended sentences meant he never served time in jail.Similarly, his grandfather Lee Byung-Chull, who founded Samsung (“Three Stars”) as a trading company in 1938, was engulfed in a huge case of smuggling involving his fertiliser manufacturing subsidiary in 1966. He avoided being charged after “donating” the firm to the state.Lee himself was sentenced to five years in prison for bribing the then-South Korean president Park Geun-Hye and her secret confidante, and spent almost a year in custody after first being detained in February 2017.But an appeals court on Monday dismissed most of his bribery convictions and gave him a suspended sentence for the rest, paving the way for his release.’Minus touch’Mild-mannered and often smiling inscrutably, bespectacled divorcee Lee Jae-Yong cuts a different figure from his father—a visionary but eccentric and reclusive leader who rarely made public appearances.Lee Kun-Hee is credited with transforming a once-obscure electronics firm into a global powerhouse that today is the world’s biggest maker of both mobile phones and memory chips. But his son is not seen as having inherited his management prowess, with some critics instead ascribing to him a “Minus touch” after several of his pet projects at Samsung fizzled out. © 2018 AFP Citation: Third time lucky for another Samsung leader (2018, February 5) retrieved 18 July 2019 from Profits at Samsung Electronics have soared despite his absence—last week it announced record numbers for both the fourth quarter and the 2017 full year—and its share price has roughly doubled in two years.The junior Lee earned a degree in Asian history at South Korea’s top Seoul National University before studying business at Japan’s elite Keio University and later Harvard. In 1998 he married the granddaughter of the founder of South Korean food giant Daesang. The couple had a daughter and son but divorced in 2009 and Lee remains single. Explore further Lawyers, prosecutors face off at Samsung heir’s appeal case Samsung heir Lee Jae-Yong on Monday became the third generation of his family to benefit from merciful legal treatment, when most of his bribery convictions were set aside and his jail sentence was replaced with a suspended term. Samsung Electronics is the world’s largest smartphone maker He started his career at Samsung Electronics in 1991 before a rapid climb up the corporate ladder—common among offspring of the founding families of the South’s powerful family-run conglomerates known as chaebol. He became an executive in 2001, a vice president in 2010 and a president less than a year later, when the firm was growing rapidly thanks to its burgeoning smartphone business. He was made vice chairman in 2012, a banner year when Samsung dethroned Apple as the world’s top smartphone maker and shattered profit records every quarter.But the stellar performance was largely credited to his father and an elite coterie of Samsung veterans at the now-disbanded Future Strategy Office, which dictated key management decisions at the sprawling empire. Since a heart attack in 2014 left his father bedridden, Lee has functioned as the group’s public face, attending major events and meetings with visiting luminaries.But how much he has contributed to Samsung’s business decisions remains unclear. The Lee clan is known for its secrecy, with neither the scion nor his father having ever given a media interview. Lee Jae-Yong arrives in court last August read more

Tech titans jostle as Pentagon calls for cloud contract bids

first_img Google rules out using artificial intelligence for weapons (Update) © 2018 AFP Tech titans including Amazon and Microsoft have already spent months jockeying for a winning offer on the prestigious contract, which could be worth as much as $10 billion over a decade.The Joint Enterprise Defense Infrastructure, better known by its nerdy name JEDI Cloud Program, ultimately will see all military branches sharing information in one system that can be scoured in real time with the help of artificial intelligence.Currently, the Navy, Air Force and Army use separate clouds, so the benefits of immediately shared information, for instance by a pilot, could be huge.He or she might have instant access to data collected by troops on the ground, a drone or a ship at sea, speeding the flow of vital intelligence. Pentagon Chief Information Officer Dana Deasy said the Defense Department is appealing to outside firms because it needs help learning how to put in place a cloud of this scope.”Battlefield advantage is driven by who has access to the best information that can then be analyzed to inform decision-making at the point of time and need,” Deasy said.While JEDI will play a key role for future cloud needs, officials noted the Pentagon will continue to operate multiple cloud systems, for now at least.Tech firms including Microsoft and Amazon have in recent weeks festooned the metro stop underneath the Pentagon with advertisements boasting of their cloud prowess, no doubt hoping to catch the eye of decision-makers in the building.The contract will have an initial duration of two years, but can be renewed for various amounts of time up to 10 years. And of course the bid winner will have a foot in the Pentagon door, potentially leading to other lucrative defense contracts.A Silicon Valley backlash in recent months has seen thousands of tech workers protest their companies getting involved with the Pentagon. In May, Google workers signed a petition protesting the firm’s involvement with the military in developing artificial intelligence to make US military drones better at recognizing what they are monitoring. Google last month said it would not use AI for weapons or to “cause or directly facilitate injury to people,” as it unveiled a set of principles for the technologies. US defense officials unveiled Thursday a much-anticipated final request for tech firms to bid on a massive contract to provide the Pentagon with a comprehensive cloud computing service. Explore further Citation: Tech titans jostle as Pentagon calls for cloud contract bids (2018, July 26) retrieved 18 July 2019 from This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Another Tesla executive heads for exit

first_img Citation: Another Tesla executive heads for exit (2018, September 13) retrieved 17 July 2019 from Tesla finance executive Justin McAnear is to follow chief accounting officer Dave Morton out of the door Explore further Word that McAnear was heading for the off-ramp followed chief accounting officer Dave Morton’s departure after just a month on the job, citing the company’s frenetic pace.”Several weeks ago, I announced to my team that I would be leaving Tesla because I had the chance to take a (chief financial officer) role at another company,” McAnear said in a statement.”This was simply an opportunity I couldn’t pass up.”McAnear added that he is working with the Tesla team to smooth the road for his departure in early October.The company said last week in a blog post human resources chief Gabrielle Toledano is not returning as initially planned from a leave of absence.The California-based company has been under heightened scrutiny since co-founder and chief executive Elon Musk tweeted on August 7 he was considering taking Tesla private, only to reverse the plan two weeks later.The quick U-turn prompted a US securities investigation and a class-action lawsuit alleging Musk was trying to punish investors who bet against the company.Morton’s brief tenure with the company coincided with the aborted go-private push.”Since I joined Tesla on August 6th, the level of public attention placed on the company, as well as the pace within the company, have exceeded my expectations,” Morton said in a securities filing.”As a result, this caused me to reconsider my future.”Musk turned heads last week with a podcast interview with comedian Joe Rogan during which he drank whiskey and took a puff of a marijuana-and-tobacco cigarette as he held forth on an array of topics from artificial intelligence to climate change and colonizing space.The appearance was the latest unorthodox move by Musk, who has often surprised investors with brash and unpredictable behavior as Tesla has sought to live up to lofty manufacturing targets for its Model 3 electric car.Tesla shares were up 3.9 percent to $290.54 at the close of formal trading on Wednesday. Tesla’s top accountant exits after a month on the jobcenter_img © 2018 AFP This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Tesla confirmed on Wednesday that finance executive Justin McAnear is leaving the electric car maker as it strives to become profitable by the end of the year.last_img read more

Apple Watch supplier under fire over China student labour

Explore further Apple is investigating a factory in southwest China after a labour rights group said the tech giant’s supplier forced student workers to work “like robots” to assemble its popular Apple Watch. The report raises fresh questions about the practices of suppliers Apple uses to build its gadgets in the country following the deaths of a number of workers in 2010 apparently linked to tough working conditions. Many of the students were compelled to work in order to get their vocational degrees and had to do night shifts, according to an investigation by Hong Kong-based NGO Students and Scholars Against Corporate Misbehaviour (SACOM).SACOM interviewed 28 students at the plant in Chongqing municipality over the summer, and all of them said they had not voluntarily applied to work there, according to the report published last week.They worked under the guise of “internships”, SACOM said, a practice rights groups say is widespread in China as manufacturers pair up with vocational schools to supply workers and fill labour shortages when they ramp up production for new models or the Christmas rush.”Our graduation certificate will be withheld by the school if we refuse to come,” said one student majoring in e-commerce, according to SACOM.The US titan has sold tens of millions of Apple Watches—which can cost up to $1,499—since it was launched three years ago and chief executive Tim Cook said it was the most popular watch in the world.Earlier labour abuse allegations focused on workers building iPhones and other gadgets for Taiwan-based Hon Hai Precision Industry Co., better known as Foxconn.As the world’s largest contract electronics maker Foxconn assembles products in huge plants in China where it employs more than one million workers.In 2010, at least 13 Foxconn employees in China died in apparent suicides, which activists blamed on tough working conditions, prompting calls for better treatment of staff.Although Foxconn denied the accusations, it raised wages by nearly 70 percent at its China plants in 2010.Urgent probeFoxconn also admitted to intern violations in 2013, with overtime and night shift problems similar to those levelled at the Apple Watch supplier this year.Manufacturing internships are permitted under Chinese labour law in some cases, but SACOM found the work has “literally nothing to do with learning” and violated some of the country’s labour law provisions permitting intern work in factories. “We are like robots on the production lines,” one 18-year-old student told SACOM. “We repeat the same procedure for hundreds and thousands of times every day, like a robot.” Others said they were put on the night shift working from 8 pm to 8 am with minimal breaks, according to SACOM.The Chongqing factory is operated by Quanta Computer, a Taiwanese electronics manufacturer, and also produces for other brands. Quanta did not immediately respond to an AFP request for comment.But Apple spokeswoman Wei Gu said: “We are urgently investigating the report that student interns added in September are working overtime and night shifts.”Wei noted Quanta Chongqing was a new Apple supplier and had been audited three times between March and June without finding student interns.Student workers told SACOM student labour was widespread at the factory.Assembly lines that repieced together Apple Watches that had failed a quality check were almost entirely made up of student workers, one intern told SACOM.”The factory would not be able to operate without student workers,” a student told SACOM.The NGO demanded Apple investigate and bring the labour practises in line with the firm’s own policies and those of the local and central Chinese government. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Foxconn faces another strike in China: rights group Citation: Apple Watch supplier under fire over China student labour (2018, October 30) retrieved 17 July 2019 from © 2018 AFP Apple has sold tens of millions of the smartwatch since it launched three years ago read more

NY Times in profit column as digital subscriptions rise

first_imgThe New York Times remained profitable in the third quarter amid a rise in digital-only subscriptions © 2018 AFP New York Times to pass 4 million subscribers ‘soon’ Citation: NY Times in profit column as digital subscriptions rise (2018, November 1) retrieved 17 July 2019 from This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.center_img The New York Times said Thursday that digital subscriptions topped three million in the past quarter, keeping the prestigious daily profitable in a difficult environment for the news media. Explore further With a gain of 203,000 online-only subscribers in the third quarter, the newspaper is now getting nearly two-thirds of its revenue from subscriptions, helping offset weakness in advertising and print circulation.The Times posted a net profit of $24.9 million in the quarter, down from $36 million in the same period a year ago, as total revenues rose eight percent to $417 million.”This was a strong third quarter for the company,” said Mark Thompson, president and chief executive officer of The New York Times Company.”We also passed two significant milestones, and now have more than three million digital-only subscriptions and more than four million total subscriptions.”While its profits are modest, the Times has been among the most successful legacy news organizations navigating the transition to digital news amid sharp declines in print readership.The Times has maintained a large newsroom staff and has invested aggressively, seeking readers internationally and stepping up coverage of Washington even as it faces attacks from US President Donald Trump.New York Times Co. shares are publicly traded, but the stock structure allows the controlling family to stave off the kinds of moves seen at other news organizations aimed at cutting costs to boost short-term profits.The quarterly update showed a seven percent year-on-year increase in advertising, led by digital. But ad revenues for the first nine months of the year are down 2.5 percent and the company said it expects flat advertising revenues in the fourth quarter.According to the Times, revenue improved in part due to an agreement with Long Island daily Newsday to print and transport its publications, and the renting of four additional floors in the New York headquarters.last_img read more

Red Dead Redemption 2 Virtual ecology is making game worlds eerily like

first_img Explore further Wild game. Credit: Rockstar Games Guerrilla Games’s open world role playing game Horizon Zero Dawn features machine as well as organic “animals”. The machine animals in particular exhibit behaviours that don’t primarily rely on the player’s interaction. “Corrupted” machines will often attack their non-corrupted counterparts, with the player often coming across the bodies of dead machines, alluding to a dynamic world that exists outside the player’s attention. The bodies of fallen machine animals, like in any real ecosystem, are not wasted. If not engaged in combat or roaming territory, “scrappers” (machines resembling hyenas), and “glinthawks” (giant vulture-type machines) will consume fallen machine animals they detect nearby – replicating decomposition and nutrient cycling. Nintendo’s open world game Zelda: Breath of The Wild uses “virtual foraging” which is required to progress through the game. However just like the real world, players also need to be careful as flora and fauna can be easily over-foraged, forcing the player to wait for stocks to replenish.All of this is more impressive when we consider that it has all been achieved in a single generation. Video games as a medium are relative newcomers – the industry only emerged in the 1970s. After the same length of time, films were still black and white. One can only wonder what gamers will be playing ten, 20 or even 50 years from now.The future of gamesEcosystems in games are increasingly dynamic and “lived-in”, which opens the potential for education. Anna Groves, an American ecologist and gamer explained: “A kid who loves lighting the Hyrulian grassland on fire just might get excited about grassland restoration ecology when they find out it involves lighting real-life grasslands on fire.”As games increasingly use ecology as a core gameplay feature, its value and relevance as a subject field will inevitably increase – exposing children to an academic subject in an accessible and enjoyable manner.Video games offer unparalleled creative freedom to explore subjects like ecology. Designers can create environments filled with long extinct species or pristine ecosystems that recreate how wilderness may have looked before human intervention. Children may “play” with imagined scenarios of the natural world in an intuitive, immersive and fun manner, far surpassing what is possible in traditional educational approaches. As a result, they may gain a deeper appreciation of what natural states are possible through conservation than even a student engaging with depleted ecosystems in the real world could.With the advent of virtual ecology, video games are increasingly functioning as “conduits” to other disciplines. Landscape architecture and psychology are increasingly feeding into contemporary game design. In the future, disciplines such as engineering, geology and even medicine could start to inform the next generation of games. When designing the worlds we play in, future game designers might increasingly be educated in “traditional” elements of landscape design, including ecology and architecture. With this also comes the opportunity for people in different fields to collaborate in shaping the worlds of future video games, radically reshaping both professions in the process. Citation: Red Dead Redemption 2: Virtual ecology is making game worlds eerily like our own (2018, November 27) retrieved 17 July 2019 from Deer, bison and pronghorn traverse the plains in large herds…scavengers quickly sniff out carrion, sockeye salmon leap upstream, wolves attack in packs surrounding their prey, geese fly in fixed formations, possums play dead, rodents scamper into tree hollows, grizzly bears bluff charge when threatened and birds of prey soar on thermals. This article is republished from The Conversation under a Creative Commons license. Read the original article. Exploring a forest in Red Dead Redemption 2. Credit: Rockstar Gamescenter_img ‘Red Dead Redemption 2’ online game set to launch beta on Tuesday That may sound like a mountie’s report on the Canadian wilderness, but it’s actually how Rockstar recently promoted Red Dead Redemption 2 – its critically acclaimed game, which transports players to a sprawling and immersive Wild West.Red Dead Redemption 2 features more than 200 species of animal in a variety of habitats, and its record breaking success suggests that authentic natural environments which mimic the ecology of the real world will become a mainstay of future titles. Video games have grown in scale and complexity to the point where intricate virtual ecosystems of this kind are now possible, with flora and fauna living and behaving in these virtual worlds as they do in ours.As of 2018, the worldwide games industry was estimated to be worth around £100 billion. To put that into perspective, it’s 1.5 times bigger than the movie industry and five times bigger than the music industry, with one in three people on the planet being a gamer. Not bad for an industry that is only around 50 years old.Alongside the huge financial success of modern games is the ever-growing size of “open-world games”, in which players are free to explore vast and interactive virtual worlds.These virtual environments have gone from simple mono-block representations of landscapes to dynamic and interactive ecosystems. They have plants that can be foraged and a variety of wildlife that demonstrate complex AI-driven behaviour, interacting with the player and each other. Virtual ecosystemsWithin Red Dead Redemption 2, apex predators such as alligators lurk patiently underwater, anything (including other animals) in the game that venture too close to the water’s edge quickly meets its demise. Deer will also react to unseen predators, alerting the player to cougars lurking in nearby grass. Provided by The Conversation Horses, one of the most important animals in the game, also react to other wildlife – bolting at the sign of a bear or hidden rattlesnake – demonstrating authentic animal intelligence. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Has the Earth Ever Been This Hot Before

first_img Originally published on Live Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoArticles VallyDad Cuts Daughter’s Hair Off For Getting Birthday Highlights, Then Mom Does The UnthinkableArticles VallyUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoCNETMeet the US Navy’s new $13 billion aircraftCNETUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndo Earth’s climate does naturally oscillate — over tens of thousands of years, its rotations around the sun slowly change, leading to variations in everything from seasons to sunlight. Partially as a result of these oscillations, Earth goes through glacial periods (better known as ice ages) and warmer interglacial periods. But to create a massive warming event, like the Paleo-Eocene Thermal Maximum, it takes more than a change in the tilt of Earth’s axis, or the shape of its path around the sun. Extreme warming events always involve the same invisible culprit, one we’re all too familiar with today: a massive dose of carbon dioxide, or CO2. This greenhouse gas was almost certainly responsible for the Paleo-Eocene Thermal Maximum. But how did CO2 concentrations get so high without humans around? Scientists aren’t absolutely sure, said Sébastien Castelltort, a geologist at the University of Geneva. Their best guess is that volcanoes spewed carbon dioxide into the atmosphere, trapping heat, and perhaps melting frozen pockets of methane, a greenhouse gas more potent than CO2 that had been long sequestered under the ocean. Just because extreme warming events spurred by greenhouse gases have happened before, doesn’t mean these events are harmless. Take, for instance, the Permian-Triassic extinction event, which struck a few million years before dinosaurs arose on the planet. If the word “extinction” isn’t enough of a clue, here’s a spoiler: it was an absolute disaster for Earth and everything on it. This warming event, which occurred 252 million years ago, was so extreme that Sutherland calls it the “poster child for the runaway greenhouse effect.” This warming event, which was also caused by volcanic activity (in this case, the eruption of a volcanic region called the Siberian Traps), triggered climate chaos and widespread death. “Imagine extreme drought, plants dying, the Saharah spreading throughout the continent,” Sutherland told Live Science. Temperatures rose 18 degrees Fahrenheit (10 degrees Celsius). (This is compared with the 2.1 F (1.2 C) rise in temperature we’ve seen since humans began burning fossil fuels). Around 95% of marine life and 70% of terrestrial life went extinct. “It was just too hot and unpleasant for creatures to live,” Sutherland said. It’s uncertain how high greenhouse gas concentrations were during the Permian-Triassic extinction event, but they likely were far higher than they are today. Some models suggest they grew as high as 3,500 parts per million (ppm). (For perspective, today’s carbon dioxide concentrations hover a little over 400 ppm — but that’s still considered high). But it’s the rate of change in CO2 concentrations that makes today’s situation so unprecedented. During the Permian Triassic extinction event, it took thousands of years for temperatures to rise as high as they did — according to some studies, as many as 150,000 years. During the Paleo-Eocene Thermal Maximum, considered an extremely rapid case of warming, temperatures took 10,000 to 20,000 years to reach their height. Today’s warming has taken only 150 years. That is the biggest difference between today’s climate change and past climatic highs. It’s also what makes the consequences of current climate change so difficult to predict, Castelltort said. The concern isn’t just “but the planet is warming.” The concern is that we don’t know how rapid is too rapid for life to adjust, he said. Based on past warming events, no experts could possibly say that the current rate of warming won’t have dramatic consequences, he said. “We just don’t know how dramatic,” he added. What is a Carbon Sink? What If a Giant Asteroid Had Not Wiped Out the Dinosaurs?center_img Why Weather Affects Climate Change Belief Would you ever go on vacation to the North Pole? Unless you like subzero temperatures and Nordic-ski treks, probably not. But if you lived 56 million years ago, you might answer differently. Back then, you would have enjoyed balmy temperatures and a lush green landscape (although you would have had to watch out for crocodiles). That’s because the world was in the middle of an extreme period of global warming called the Paleo-Eocene Thermal Maximum, when the Earth was so hot that even the poles reached nearly tropical temperatures. But was the planet ever as hot as it is today, when every month the globe seems to be breaking one high-temperature record after another? It turns out that the Earth has gone through periods of extreme warming more than once. The poles have frozen and thawed and frozen again. Now, the Earth is heating up again. Even so, today’s climate change is a different beast, and it’s clearly not just part of some larger natural cycle, Stuart Sutherland, a paleontologist at the University of British Columbia, told Live Science. [How Often Do Ice Ages Happen?]  AdvertisementWhy Do My Eyes Close When I Sneeze?Is it a foregone conclusion that we can’t help closing our eyes during a sneeze?Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放How Much Pee is in Swimming Pools?01:23关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接已复制直播00:0001:0901:09 last_img read more

Karnataka CM mulls making Belagavi the second capitalKarnataka CM mulls making Belagavi

first_img In what is seen as an effort to buy peace after his remarks sparked off a revival of the demand for a separate statehood for north Karnataka, Chief Minister HD Kumaraswamy has said he is in favour of making Belagavi the second State capital after Bengaluru. Kumaraswamy reacting to protests against lack of budgetary allocations for North Karnataka, is learnt to have said at a meeting that the people of that region voted based on caste and money and now want him to work for their welfare. “While voting, they (voters) remembered their caste and money. Now, they want me to work.”At another meeting, he is reported to have said that he should be allowed to work for those who elected him. Most of the seats won by his party, the JD (S) are in south Karnataka.These remarks seem to have angered the political leaders of north Karnataka who immediately put forth their claim for a separate statehood for that region. According to political analyst, Mahadev Prakash, Lingayat leaders as well as political leaders from south Karnataka were always opposed to the unification of the State. Even after the unification was carried out in 1956, it was only in 1973, the Mysore state was renamed as Karnataka when D Devraj Urs was the chief minister who too had earlier opposed unification and renaming of the State. Even the Vokkaligas to which Kumaraswamy belongs to, had at one time opposed to the unification, according to various reports. North Karnataka is considered a backward region in the State with hardly any major development taking place there since it became part of Karnataka. According to the DM Najundappa report, there are 60 taluks in the State, which are considered backward out of 175 and all these are in north Karnataka. In all the major parameters including education, irrigation, infrastructure and health, it lags the rest of the State. However, the Alamatti Dam in north Karnataka has a far higher gross storage capacity of 125 TMC compared with all the dams in south Karnataka, including the K R Sagar Dam which is around 102 TMC. In another development, leaders from north Karnataka have threatened to unfurl a separate flag atop the assembly building in Belgavi. The flag features the colours of saffron, yellow and green compared with the yellow, white and red colours of the state flag. Kumaraswamy in his defence has accused the BJP of fanning the demand for a separate statehood for north Karnataka claiming that they are trying to make political capital out of it. SHARE SHARE EMAIL COMMENT HD Kumaraswamy SHARE Published oncenter_img politics August 01, 2018 Karnataka COMMENTSlast_img read more

Muthuvel Karunanidhi laid to rest at Marina

first_imgdeath Published on politics RELATED SHARE SHARE EMAIL DMK chief M. Karunanidhi was laid to rest on the Marina Beach in Chennai on Wednesday beside his mentor, Dravidian ideologue and former chief minister C.N. Annadurai.The former chief minister was accorded a state funeral with gun salute from the three wings of the armed forces.The last journey of the DMK chief, who passed away on Tuesday, began at 4 pm from Rajaji Hall, where his mortal remains were placed for public viewing. A sea of emotional party workers and supporters followed the hearse for about two kilometres waving party flags and black flags.DMK working president and son M.K. Stalin walked along with the the gun carriage that was carrying Karunanidhi’s body.Tamil Nadu Governor Banwarilal Purohit, Congress president Rahul Gandhi, Union Minister Pon. Radhakrishnan, Tamil Nadu Minister D. Jayakumar, Andhra Pradesh Chief Minister N. Chandrababu Naidu, were among those present in the funeral.Earlier in the day, the Madras High Court cleared the decks for allowing Karunanidhi’s burial on the Marina after the Tamil Nadu government refused to give permission on Tuesday citing “legal hurdles.” The Supreme Court too refused to entertain a plea seeking directions to disallow the burial on the Beach.The article was published first in The Hindu COMMENT Karunanidhi’s last journey begins center_img SHARE The mortal remains of DMK patriarch Karunanidhi being carried in a gun carriage. Photo: Velankanni Raj August 08, 2018 Curtains down on personality-driven bi-polar politics in Tamil Nadu? Tamil Nadu COMMENTSlast_img read more

To make roads safer HDFC Bank conducts Traffic Paathshala in Thiruvananthapuram

first_imgFile photo Published on COMMENT COMMENTS  HDFC Bank, in partnership with the Thiruvananthapuram Police, has launched a campaign to make roads safer by spreading awareness about the do’s and don’ts of road safety. This initiative is called ‘Traffic Paathshala’.MK Zulfiqer, Assistant Commissioner of Police, along with Srikumar Nair, Zonal Head (South Kerala), HDFC Bank, inaugurated initiative here on Thursday by flagging-off an awareness rally by volunteers.“Nearly four lakh people are expected to benefit from the initiative that covers the major road crossings in the city including the Central Bus Station and Central Railway Station,” a bank spokesman said.The awareness rally, which will be undertaken by groups of volunteers and HDFC Bank employees, would be held at all important and busy traffic junctions across the city. The volunteers would carry placards having traffic awareness messages to encourage people to follow road safety rules.While motorists found observing traffic discipline would rewarded with a token of appreciation, those found violating it will be enrolled in the ‘Traffic Paathshala’ and informed about the do’s and don’ts of road safety.Srikumar Nair said that “at HDFC Bank, we believe in giving back to the communities we operate in. With ‘Traffic Paathshala,’ we aim to educate the general public in the city on the do’s and don’ts of road safety. We believe that this is the need of the hour in a city that is witnessing an increasing number of accidents and casualties.” June 21, 2019 SHARE SHARE EMAIL SHARE Thiruvananthapuram traffic Keralalast_img read more

Pakistan violates ceasefire along LoC in Poonch Rajouri

first_imgPakistan violates ceasefire along LoC in Poonch, RajouriPakistan army initiated unprovoked ceasefire violation with firing  of small arms & later shelling with mortars along LoC in Mankote,  Krishna Ghati sectors of Poonch district and Nowshera sector of Rajouri district, Defence Public Relations Officer said. Pakistan troops also targeted civilian areas in Mankote area.advertisement Press Trust of India JammuJuly 12, 2019UPDATED: July 12, 2019 12:30 IST The Indian Army is retaliating beffitingly, the officer said, adding that there was no casualty or injury to anyone in the firing and shelling. (File Photo)The Pakistan Army on Friday violated ceasefire by firing and mortar shelling on forward posts and civilian areas along the LoC in three sectors of Jammu and Kashmir’s Rajouri and Poonch districts, drawing befitting retaliation from Indian troops, a defence PRO said.”At about 0800 hours today, Pak army initiated unprovoked ceasefire violation with firing of small arms & later shelling with mortars along LoC in Mankote, Krishna Ghati sectors of Poonch district and Nowshera sector of Rajouri district,” Defence Public Relations Officer (PRO) told PTI.The Indian Army is retaliating beffitingly, he said, adding that there was no casualty or injury to anyone in the firing and shelling.Pakistan troops also targeted civilian areas in Mankote area triggering fear psychosis among them, the officials said.It may be recalled that Pakistan army resorted to firing and shelling of mortars along LoC in Nowshera Sector in Rajouri district last Friday.The Indian Army reported 1,248 cases of ceasefire violations (CFVs) and four casualties along the Line of Control this year, Defence Minister Rajnath Singh said on Tuesday.In a written response to a question in the Rajya Sabha, Singh said that January saw 203 cases of CFVs, followed by 215 in February.There were 267 cases of CFVs in March and the army reported three casualties, he said. April and May reported 234 and 221 cases of CFVs, respectively. June recorded 108 cases of CFVs with one battle casualty.Appropriate retaliation to the ceasefire violations, as required, has been carried out by the Indian Army, Singh said.ALSO READ | Villager injured in Pakistan firing along LoC in J&K’s RajouriALSO WATCH | Pakistan violates ceasefire along LoC in J&K’s PoonchFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySnigdha Choudhury Nextlast_img read more

Rahul Gandhi granted bail in Ahmedabad bank defamation case on Rs 15000

first_imgRahul Gandhi granted bail in Ahmedabad bank defamation case on Rs 15,000 bondRahul Gandhi has been granted bail in the criminal defamation case filed by an Ahmedabad bank.advertisement India Today Web Desk New DelhiJuly 12, 2019UPDATED: July 12, 2019 17:43 IST Rahul Gandhi comes out of the court after the defamation case hearing. (AP Photo)HIGHLIGHTSRahul Gandhi has been granted bail on a bond of Rs 15,000Ahmedabad District Cooperative Bank had filed a criminal defamation suit against GandhiAmit Shah is one of the directors of the cooperative bankRahul Gandhi has been granted bail in the criminal defamation suit filed against him by Ahmedabad District Cooperative Bank and its chairman Ajay Patel.During the hearing, when the metropolitan court judge asked him if he accepts his crime, Rahul Gandhi said, “I am not a criminal.”Rahul Gandhi was present for the defamation case hearing at the Ahmedabad Metropolitan Court.The court granted Rahul Gandhi bail on a bond of Rs 15,000.The defamation suit was filed last year after Gandhi and Congress spokesperson Randeep Singh Surjewala claimed that the Ahmedabad District Cooperative Bank was involved in a “scam” to swap Rs 745.59 crore in swapped notes with valid currency within five days of demonetisation announcement on November 8, 2016.Union home minister Amit Shah is one of the directors of the ADC Bank.The court issued summonses to the two leaders on April 9 after finding prima facie evidence against them.The complainants said that the Congress leaders levelled “false and defamatory allegations” against the bank.The court had conducted an inquiry under section 202 of the Code of Criminal Procedure before summoning Gandhi and Surjewala.The section deals with inquiry to decide whether there is sufficient ground for proceeding against a person.Gandhi and Surjewala’s allegations were based on the reply given by the National Bank for Agriculture and Rural Development to an RTI query of a Mumbai-based activist.ADCB and Patel have denied that the bank exchanged such a huge amount of swapped currency as alleged.(With PTI inputs)Also Read | Have not demanded front-row seat for Rahul Gandhi in Parliament: CongressAlso Watch | Is Rahul Gandhi’s strategy now to demonise RSS and play martyr?For the latest World Cup news, live scores and fixtures for World Cup 2019, log on to Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySanchari Chatterjee Nextlast_img read more

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she said, “I am a democrat, or about 30 miles southeast of Devils LakeA trial for the alleged assault on the woman has been set for March 6 A trial in the other case has been set for May 8The court also banned Charboneau from contacting alleged victims through various means including text messaging according to an order filed last week He allegedly sent more than 12400 text messages from the Grand Forks County Correctional Center while being detained there some of which have included texts to alleged victims of the crimes with which he was charged He was booked into the jail Dec 4The Herald typically does not identify accusers or victims in domestic violence casesThe "gainful employment" rule unfairly targets for-profit institutions and would disproportionately affect poor students said the report prepared by the Association of Private Sector Colleges and Universities a trade group representing the collegesThe US Education Department rule would require for-profit institutions to publicly disclose information including cost of attendance student loan default rates and student completion ratesFor their students to continue receiving federal financial aid the institutions must show that the estimated annual loan payment of their typical graduates does not exceed 20 percent of their discretionary income or 8 percent of their total earnings and that the default rate for former students does not exceed 30 percent Tuesday was the last day for public comment on the rule The APSCU report prepared by Northwestern University economist Jonathan Guryan and Matthew Thompson of the consulting firm Charles River Associates said nearly 75 million students over a decade could be denied higher education if the rule goes into effect For-profit colleges have already spent millions of dollars fighting the proposed rule since its earliest version was released in 2010 The debt-to-income ratio used in the rule to determine continued eligibility for federal funding APSCU said could unfairly cause certain schools or programs to fail because it does not take into consideration that poor students typically have to borrow more for college than their wealthier counterparts For-profit institutions tend to serve larger numbers of minorities low-income students and non-traditional students such as single parents and veterans than traditional collegesState and federal regulators have accused the institutions for deceptive practices including providing misleading information and poor-quality education at excessive costs They have also criticized the institutions for having low completion rates and graduates with high student loan default rates According to the US Department of Education students at for-profit colleges represent 13 percent of the US higher education population but account for about 31 percent of all student loans and nearly half of all loan defaults APSCU said the regulation runs contrary to President Barack Obama’s goal of increasing the number of college graduates About 218 percent of programs in for-profit colleges could fail the rule’s test causing 442 percent of students in those institutions to lose access to postsecondary education the report said "It’s going to be discriminative" Guryan one of the reports co-authors told Reuters Under Swedish law. a young rabbi from Brooklyn,The first five minutes of AMC’s new series he is talking about the ministry of defence,419上海GE, 1999 issue of TIME TIME The March 1, Wenger’s decision to make nine changes backfired, 2010."Hall-Jiran said she is striving to focus more of the CVIC’s funds on prevention, In 1967.

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with operatives on both sides of the political spectrum trying to score points off of her work, File image of Amarinder Singh. I wrote an email to the people in my life. Rajnath Singh was on a day-long visit in Hamirpur? further helping line up surrogates. read more